Common sexual health considerations for GLP-1 patients

As more people begin to use GLP-1 medications, healthcare providers are observing lifestyle and sexual health implications that may call for a reassessment of current contraceptive methods. Here’s what to know — and why people on GLP-1s should take a moment to evaluate whether their contraceptive choice is still the right fit for this new phase of life, and where barrier contraceptives like FC2 come in.

Reduced effectiveness of hormonal contraceptives

Manufacturers note that certain GLP-1s may make oral hormonal contraceptives less effective. Mounjaro’s (generic: tirzepatide) prescribing information, for example, advises patients to use an alternative contraceptive method for 4 weeks after starting the medication and for 4 weeks after each dose increase.

Improved fertility

GLP-1s may improve insulin sensitivity, reduce PCOS symptoms, or lower inflammation — all of which can increase your fertility, sometimes unexpectedly.

Vaginal changes

Some patients experience decreased lubrication and loss of pelvic floor strength as a result of rapid weight loss and metabolic shifts.

Irregular cycles or hormonal shifts

Temporary changes in menstrual patterns have been observed during GLP-1 treatment. Changes to your ovulation can indicate changes to hormone levels.

Changes in libido or arousal

Fluctuating desire and changes in the ability to maintain an erection have been reported by some patients.

Fatigue and GI symptoms

Common side effects like nausea and fatigue can impact energy levels and overall comfort during intimacy.

What is FC2?

FC2 is an FDA-approved, latex-free internal condom. It provides non-hormonal barrier protection against both STIs and pregnancy. Worn internally by the receiving partner, FC2 can be inserted ahead of time and offers an alternative for those who need or prefer non-hormonal contraception.

Why FC2 may be a strong fit for patients using GLP-1s

Fatigue and GI symptoms

Certain GLP-1s may interfere with hormonal contraceptives, particularly during the early weeks of treatment or after a dose increase, and may improve fertility. Adding a barrier contraceptive method can be a practical way to reduce increased pregnancy risk.

Additionally, patients taking GLP-1 therapies are already managing metabolic and hormonal changes. As a non-hormonal contraceptive option, FC2 offers an accessible choice for those who want to avoid additional effects on hormones or the menstrual cycle.

Designed for comfort

FC2 is pre-lubricated on both sides and made of soft, flexible nitrile, which can help reduce friction and irritation during use. Because it’s worn internally and lines the vaginal canal, some friction may be shifted from the receiving partner to the penetrating partner. This can be more comfortable for individuals experiencing vaginal dryness or other discomfort related to metabolic, hormonal, or weight changes.

Changes in libido or arousal

Side effects of GLP-1s such as nausea, fatigue, or stress can impact arousal or sexual performance. Additionally, some patients report increased difficulty maintaining an erection after starting or increasing their dose of GLP-1s. Because FC2 is worn internally by the receiving partner, it does not rely on an erection, helping reduce pressure and support intimacy on the patient’s terms.

FC2 Accessible and Patient-controlled

While FC2 requires a prescription, it doesn’t require an in-person visit, and it’s easy to start and stop based on your needs. It’s an option for those who can’t use external condoms or don’t find them comfortable—especially during the physical changes that can come with GLP-1 use.

Protecting your health is all about finding what works best for you. There’s no one-size-fits-all approach — it’s about making choices that fit your needs and feel right for your lifestyle.

As the only FDA-approved, female-controlled condom that protects against unintended pregnancy and STIs, the FC2 Female Condom could be a great option if you’re exploring different protection methods. Getting protection shouldn’t mean breaking the bank, either — with a prescription, FC2 may be available for as little as $0, depending on your insurance (check with your provider about your plan’s coverage!).

Curious to see if FC2 is right for you? Check out our guide on how to use FC2 and our FAQ page to get all the details and see how it works!